Open access

Papers, explained

338 open-access papers, free to watch.

Virtual simulation in healthcare education: a multi-professional, pan-Canadian evaluation

Virtual simulation in healthcare education: a multi-professional, pan-Canadian evaluation

Margaret Anne Verkuyl, Efrem Mauro Violato, Nicole Harder, Theresa Southam, Mélanie Lavoie‐Tremblay, Sandra Goldsworthy, Wendy D. Ellis, Suzanne Campbell, Lynda Atack

Healthcare students need real clinical experience, but hospitals cannot always provide enough placements. This study asks whether a screen-based patient encounter can help prepare them, and finds that simply adding one is not enough.

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Impaired bisecting GlcNAc reprogrammed M1 polarization of macrophage

Impaired bisecting GlcNAc reprogrammed M1 polarization of macrophage

Xin He, Bowen Wang, Wenli Deng, Jinhua Cao, Zengqi Tan, Xiang Li, Feng Guan

Immune cells can help attack a tumor or help it grow. This study suggests that a tiny sugar pattern on their surface helps decide which role they take, and removing it pushes them toward attack.

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The effects of a firm’s internationalization, age, and environmental turbulence on the capabilities that comprise strategic agility

The effects of a firm’s internationalization, age, and environmental turbulence on the capabilities that comprise strategic agility

Enrique de Diego Ruiz, Paloma Almodóvar, Julian Birkinshaw

When the business world becomes more chaotic, companies do not always become less capable. This study finds that turbulence can actually make them more alert, more responsive, and better able to adapt.

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Distribution, health and threats to Mediterranean macroalgal forests: defining the baselines for their conservation and restoration

Distribution, health and threats to Mediterranean macroalgal forests: defining the baselines for their conservation and restoration

Jana Verdura, Lluc Rehues, Luisa Mangialajo, Simonetta Fraschetti, Zahira Belattmania, Silvia Bianchelli, Aurélie Blanfuné, Brahim Sabour, Antonia Chiarore, Roberto Danovaro, Erika Fabbrizzi, Sylvaine Giakoumi, Ljiljana Iveša, Stelios Katsanevakis, Eleni Kytinou, Ina Nasto, Athanasios Nikolaou, Sotiris Orfanidis, Gil Rilov, Fabio Rindi, Marta Sales, Maria Sini, Laura Tamburello, Thierry Thibaut, Konstantinos Tsirintanis, Emma Cebrián

Under the Mediterranean surface, forests made of large algae shelter life and support the sea’s workings. Yet the hardest part of saving them may be that, across much of the coast, nobody has measured their condition clearly enough.

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‘Unprecedented injustice’: Digitalisation and the perceived accessibility of childcare benefits

‘Unprecedented injustice’: Digitalisation and the perceived accessibility of childcare benefits

Bryn Hummel, Mara A. Yerkes, Michèlle Bal

A benefit can exist on paper and still feel out of reach. In the Netherlands, parents with more education actually reported lower access to childcare benefits, a result that turns the usual story about inequality upside down.

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Tetra-O-methyl-nordihydroguaiaretic acid inhibits energy metabolism and synergistically induces anticancer effects with temozolomide on LN229 glioblastoma tumors implanted in mice while preventing obesity in normal mice that consume high-fat diets

Tetra-O-methyl-nordihydroguaiaretic acid inhibits energy metabolism and synergistically induces anticancer effects with temozolomide on LN229 glioblastoma tumors implanted in mice while preventing obesity in normal mice that consume high-fat diets

Kotohiko Kimura, Jong Ho Chun, Yu‐Ling Lin, Yu‐Chuan Liang, Tiffany L. B. Jackson, Ru Chih C. Huang

What if a cancer treatment could attack a tumor by disrupting its energy supply, and work more strongly when paired with an existing drug? In mice, that is what this study found, while the same substance also limited weight gain on a high-fat diet.

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Assessment of the oxidative stress intensity and the integrity of cell membranes under the manganese nanoparticles toxicity in wheat seedlings

Assessment of the oxidative stress intensity and the integrity of cell membranes under the manganese nanoparticles toxicity in wheat seedlings

Apolonia Sieprawska, Elżbieta Rudolphi-Szydło, Magdalena Skórka, Anna Telk, Maria Filek

Tiny manganese particles sprayed onto wheat leaves did not simply sit on the surface. They entered the leaves, triggered a stress response, and quietly changed the membranes inside the plant.

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Constructing custom thermodynamics using deep learning

Constructing custom thermodynamics using deep learning

Xiaoli Chen, Beatrice W. Soh, Zi‐En Ooi, Eléonore Vissol-Gaudin, Haijun Yu, Kostya S. Novoselov, Kedar Hippalgaonkar, Qianxiao Li

A molecule can look ready to stretch, yet take a very different path from another molecule that looks identical. This study teaches artificial intelligence to uncover the hidden information that explains why.

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Real-time PCR detection of mixed Plasmodium ovale curtisi and wallikeri infections in human and mosquito hosts

Real-time PCR detection of mixed Plasmodium ovale curtisi and wallikeri infections in human and mosquito hosts

Varun R. Potlapalli, Meredith Muller, Billy Ngasala, Innocent Mbulli Ali, Yu Bin Na, Danielle R. Williams, Oksana Kharabora, Srijana Chhetri, Mei S. Liu, Kelly Carey-Ewend, Feng‐Chang Lin, Derrick K. Mathias, Brian B. Tarimo, Jonathan J. Juliano, Jonathan B. Parr, Jessica T. Lin

A malaria infection that looks like one may actually contain two closely related species. The surprise is that mosquitoes revealed mixed infections far more often than human blood tests did.

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Electrical and magnetic properties of antiferromagnetic semiconductor MnSi2N4 monolayer

Electrical and magnetic properties of antiferromagnetic semiconductor MnSi2N4 monolayer

Dongke Chen, Zhengyu Jiang, Ying Tang, Junlei Zhou, Yuzhou Gu, Jingjing He, Jiaren Yuan

Imagine a sheet so thin that its electrons can be made to choose sides: one direction flows like metal, while the other is blocked like a semiconductor. This study predicts a material that can do exactly that.

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Comprehensive analysis regarding the prognostic significance of downregulated ferroptosis-related gene AKR1C2 in gastric cancer and its underlying roles in immune response

Comprehensive analysis regarding the prognostic significance of downregulated ferroptosis-related gene AKR1C2 in gastric cancer and its underlying roles in immune response

Wei Liu, Fan Zhang, Keda Yang, Yuanliang Yan

In stomach cancer, a gene involved in a form of cell death appears in smaller amounts than usual. The surprising part is that patients with more of this gene tended to have better outcomes.

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Impacts of climate change–simulated flooding and drought events–on terrestrial invertebrates (Enchytraeids and Collembolans)

Impacts of climate change–simulated flooding and drought events–on terrestrial invertebrates (Enchytraeids and Collembolans)

Rita C. Bicho, Janeck James Scott-Fordsmand, Mónica J.B. Amorim

A flood or drought may not kill the tiny animals in soil. The more troubling result is that they can survive while producing far fewer offspring, quietly changing the life of the soil beneath us.

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