Open access

Papers, explained

338 open-access papers, free to watch.

KDM3A Ablation Activates Endogenous Retrovirus Expression to Stimulate Antitumor Immunity in Gastric Cancer

KDM3A Ablation Activates Endogenous Retrovirus Expression to Stimulate Antitumor Immunity in Gastric Cancer

Jiabin Zheng, Huolun Feng, Jiatong Lin, Jianlong Zhou, Zhihui Xi, Yucheng Zhang, Fa Ling, Yongfeng Liu, Junjiang Wang, Tieying Hou, Fan Xing, Yong Li

Some stomach tumors are difficult for immune treatments to see. This study found that quieting one gene can make tumor cells sound an internal alarm, drawing stronger immune attacks and helping treatment work better.

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Factors Associated with Fertility Intention among Chinese Married Youth during the COVID-19 Pandemic

Factors Associated with Fertility Intention among Chinese Married Youth during the COVID-19 Pandemic

Ruicheng Peng, Wei Mou, Peng Xu

Why would married young people want fewer children even when governments encourage larger families? This study points to an unexpected answer: pandemic-related worries may matter more than money or job security.

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The HOX code of human adult fibroblasts reflects their ectomesenchymal or mesodermal origin

The HOX code of human adult fibroblasts reflects their ectomesenchymal or mesodermal origin

Lucie Pfeiferová, Michal Španko, Jana Šáchová, Miluše Hradilová, Kenneth J. Pienta, Jaroslav Valach, Vladimír Machoň, B Vymolová, Aleksi Šedo, Petr Bušek, Pavol Szabó, Lukáš Lacina, Péter Gál, Michal Kolář, Karel Smetana

Two fibroblasts can look almost identical under a microscope, yet one may still carry a molecular record of the body region it came from, and that record can remain visible in cancer.

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Market integration and economic growth

Market integration and economic growth

Shiqi Lyu, Z. Chen, Simei Pan, Lianhua Liu

We usually expect connected markets to make everyone better off. But across nine Chinese cities, this study finds that stronger market integration was linked to weaker growth locally, and did little for nearby cities.

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Therapeutic Options for Crigler–Najjar Syndrome: A Scoping Review

Therapeutic Options for Crigler–Najjar Syndrome: A Scoping Review

Vanessa Sambati, Serena Laudisio, Matteo Motta, Susanna Esposito

For some children, staying alive can mean lying under special blue lights for ten to twelve hours every day. This review asks whether future treatments could repair the problem instead of managing it for life.

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The implementation and impacts of the Comprehensive Care Standard in Australian acute care hospitals: a survey study

The implementation and impacts of the Comprehensive Care Standard in Australian acute care hospitals: a survey study

Beibei Xiong, Christine Stirling, Daniel X. Bailey, Melinda Martin‐Khan

A hospital can have skilled professionals, a national care standard, and still fail to give every patient one joined-up plan. This study found that confidence was high, but the support needed to make care consistent was not.

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Development and validation of the Japanese version of the Bedtime Procrastination Scale (BPS-J)

Development and validation of the Japanese version of the Bedtime Procrastination Scale (BPS-J)

Megumi Hazumi, Aoi Kawamura, Takuya Yoshiike, Kentaro Matsui, Shingo Kitamura, Ayumi Tsuru, Kentaro Nagao, Naoko Ayabe, Tomohiro Utsumi, Muneto Izuhara, Mio Shinozaki, Eriya Takahashi, Michio Fukumizu, Momo Fushimi, Satomi Okabe, Taisuke Eto, Daisuke Nishi, Kenichi Kuriyama

Going to bed late is not always a scheduling problem. Sometimes people intend to sleep, have no good reason to stay up, and still keep delaying bedtime. This study asks how that pattern can be measured in Japan.

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Comparative Study of Field-Effect Transistors Based on Graphene Oxide and CVD Graphene in Highly Sensitive NT-proBNP Aptasensors

Comparative Study of Field-Effect Transistors Based on Graphene Oxide and CVD Graphene in Highly Sensitive NT-proBNP Aptasensors

Anastasiia Kudriavtseva, Stefan Jarić, Nikita Nekrasov, А. В. Орлов, Ivana Gadjanski, Ivan Bobrinetskiy, Petr I. Nikitin, Nikola Ž. Knežević

Could a saliva sample reveal signs of heart failure without a blood draw? This study found that a less perfect form of graphene could detect the signal more reliably than the cleaner, more orderly version.

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Aquaporins in Biliary Function: Pathophysiological Implications and Therapeutic Targeting

Aquaporins in Biliary Function: Pathophysiological Implications and Therapeutic Targeting

Mohamad Khalil, Patrizia Gena, Agostino Di Ciaula, Piero Portincasa, Giuseppe Calamita

Bile is almost entirely water, yet tiny water channels may help decide whether it flows normally, concentrates safely, or contributes to disease. This review asks whether those channels could become treatment targets.

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Observation and quantitative analysis of dislocations in steel using electron channeling contrast imaging method with precise control of electron beam incident direction

Observation and quantitative analysis of dislocations in steel using electron channeling contrast imaging method with precise control of electron beam incident direction

Takashige Mori, Takafumi Amino, Chie Yokoyama, Shunsuke Taniguchi, Takayuki Yonezawa, Akira Taniyama

Steel can look solid and flawless while tiny lines of damage are quietly shaping how it bends, cracks, or holds together. This study finds a way to make those hidden lines visible without always cutting the steel into a thin slice.

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Relevant Membrane Transport Proteins as Possible Gatekeepers for Effective Pharmacological Ascorbate Treatment in Cancer

Relevant Membrane Transport Proteins as Possible Gatekeepers for Effective Pharmacological Ascorbate Treatment in Cancer

Christian Leischner, Luigi Marongiu, Alban Piotrowsky, Heike Niessner, Sascha Venturelli, Markus Burkard, Olga Renner

Vitamin C may help attack some hard-to-treat cancers, but the decisive question may be whether the cancer cell has the right doorways to let the treatment in. This review explains why those doors could guide treatment choices.

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A qualitative quantitative mixed methods study of domestic violence against women

A qualitative quantitative mixed methods study of domestic violence against women

Mina Shayestefar, Mohadese Saffari, Razieh Gholamhosseinzadeh, Monir Nobahar, Majid Mirmohammadkhani, Seyed Hossein Shahcheragh, Zahra Khosravi

Domestic violence is not only a private crisis. This study finds that it can be widespread, hidden by silence, and tied to beliefs that make harmful behavior seem ordinary.

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