Pharmacology, Toxicology and Pharmaceutics

2 open-access papers in Pharmacology, Toxicology and Pharmaceutics, free to watch.

4:07

Age-stratified reporting of immune checkpoint inhibitor-associated myocarditis: disproportionality is amplified in older adults, with implications for geriatric oncology

Murat Pehlivan, Aybüke Uyar, Okan Turhan, Özge Özgün, Oğuz Kayabaşı, Arzu Okyar Baş, Cafer Balcı, Burcu Balam Doğu, Meltem Gulhan Halil, Mustafa Cankurtaran, Mert Eşme

Immunotherapy can help the immune system fight cancer, but the heart can become an unintended target. This study found that the warning signal for heart inflammation was stronger in older patients across every treatment examined. Immune checkpoint inhibitor myocarditis is not just reported more often in older adults because they receive these drugs more often. This study finds that myocarditis takes up a larger share of reports within older adults’ own reporting background.

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3:39

Trends in industry payments and volume and distribution of robot-assisted surgeries

Katia Noyes, Ajay A. Myneni, Aaron B. Hoffman, Joseph D. Boccardo, Lorin M. Towle-Miller, Taylor Brophy, Steven D. Schwaitzberg

Robotic surgery is becoming more common, but the important question is not only whether it works. It is also who is helping surgeons learn to use it, and what else is being measured. Robotic surgery is expanding alongside industry payments, but the most striking pattern is not simply that companies pay surgeons. It is where the money goes, where the operations happen, and what remains uncertain.

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