Paperi
Open access

Papers, explained

338 open-access papers, free to watch.

Water compatible silica supported iron trifluoroacetate and trichloroacetate: as prominent and recyclable Lewis acid catalysts for solvent-free green synthesis of hexahydroquinoline-3-carboxamides 3:12

Water compatible silica supported iron trifluoroacetate and trichloroacetate: as prominent and recyclable Lewis acid catalysts for solvent-free green synthesis of hexahydroquinoline-3-carboxamides

Dnyaneshwar Purushottam Gholap, Ramdas Huse, Sudarshan S. Dipake, Machhindra K. Lande

Many chemical reactions depend on substances that are difficult to recover and can pollute the process. This study describes a solid helper that works without a solvent, works in water, and can be used again.

OverviewIn depth

Objective analysis of partial three-dimensional rotator cuff muscle volume and fat infiltration across ages and sex from clinical MRI scans 3:09

Objective analysis of partial three-dimensional rotator cuff muscle volume and fat infiltration across ages and sex from clinical MRI scans

Lara Riem, Silvia S. Blemker, Olivia DuCharme, Elizabeth B. Leitch, Matthew Cousins, Ivan J. Antosh, Mikalyn Defoor, Andrew J. Sheean, Brian C. Werner

A shoulder MRI often captures only part of the shoulder blade. This study finds that partial images can still reveal meaningful three-dimensional changes in the muscles that help lift and stabilize the arm.

OverviewIn depth

Current and preservice teachers' views and beliefs regarding martial arts and the inclusion of martial arts in Australian school settings: A cross‐sectional study 3:14

Current and preservice teachers' views and beliefs regarding martial arts and the inclusion of martial arts in Australian school settings: A cross‐sectional study

Louis David Burt, Nicholas Riley, Narelle Eather

Schools may be missing an activity that teachers already see as valuable. The surprising barrier is not widespread opposition, it is that many teachers support martial arts in schools while feeling unprepared to teach it.

OverviewIn depth

Local administration of mRNA encoding cytokine cocktail confers potent anti-tumor immunity 4:09

Local administration of mRNA encoding cytokine cocktail confers potent anti-tumor immunity

Zhigang Li, Ling Hu, Yiping Wang, Qi Liu, Jun Liu, Haiyan Long, Qi Li, Liping Luo, Yucai Peng

Cancer treatments often struggle with a basic problem: how do you wake up the immune system without inflaming the whole body? This study tries a more local answer, deliver the instructions directly inside the tumor.

OverviewIn depth

The Association of Plasma Homocysteine Concentrations with a 10-Year Risk of All-Cause and Cardiovascular Mortality in a Community-Based Chinese Population 3:31

The Association of Plasma Homocysteine Concentrations with a 10-Year Risk of All-Cause and Cardiovascular Mortality in a Community-Based Chinese Population

Zhe Liang, Kaiyin Li, Hongyu Chen, Jia Jia, Jianping Li, Yong Huo, Fangfang Fan, Yan Zhang

A substance in the blood was linked with a higher chance of dying over the next decade, but the strength of that link depended partly on a person’s inherited biology.

OverviewIn depth

Bacteriophage-derived endolysins as innovative antimicrobials against bovine mastitis-causing streptococci and staphylococci: a state-of-the-art review 5:03

Bacteriophage-derived endolysins as innovative antimicrobials against bovine mastitis-causing streptococci and staphylococci: a state-of-the-art review

Niels Vander Elst

Mastitis harms cows, dairy farms, and treatment choices, but a virus-made enzyme may offer a way to break the bacteria’s defenses without relying only on antibiotics.

OverviewIn depth

BrainAGE as a measure of maturation during early adolescence 3:27

BrainAGE as a measure of maturation during early adolescence

Lucy Whitmore, Sara J. Weston, Kathryn L. Mills

A brain scan can be turned into an estimated age, but does that number really tell us how mature a young person is? This study finds that it tracks puberty, but not reliably the thinking skills people may expect.

OverviewIn depth

Comparing the performance of machine learning and conventional models for predicting atherosclerotic cardiovascular disease in a general Chinese population 3:55

Comparing the performance of machine learning and conventional models for predicting atherosclerotic cardiovascular disease in a general Chinese population

Zihao Fan, Zhi Du, Jinrong Fu, Ying Zhou, Pengyu Zhang, Chuning Shi, Yingxian Sun

Heart disease remains the world's leading cause of illness and death, yet the familiar risk calculators can misjudge some people. A computer trained on many kinds of health information may offer a better warning.

OverviewIn depth

Assessment of Hygiene Management Practices and Comparative Analysis of Regulatory Frameworks for Shared Kitchens across Different Countries 3:58

Assessment of Hygiene Management Practices and Comparative Analysis of Regulatory Frameworks for Shared Kitchens across Different Countries

Yu Jin Na, Jin Young Baek, So Young Gwon, Ki Sun Yoon

A kitchen shared by many food businesses might sound like a recipe for contamination. But this study found that the more openly some kitchens were shared, the cleaner and safer they were.

OverviewIn depth

MCL1 inhibition targets Myeloid Derived Suppressors Cells, promotes antitumor immunity and enhances the efficacy of immune checkpoint blockade 4:25

MCL1 inhibition targets Myeloid Derived Suppressors Cells, promotes antitumor immunity and enhances the efficacy of immune checkpoint blockade

Nabanita Mukherjee, Elizabeth Katsnelson, Tonya M. Brunetti, Kylie Michel, Kasey L. Couts, Karoline A. Lambert, William A. Robinson, Martin D. McCarter, David A. Norris, Richard P. Tobin, Yiqun G. Shellman

What if a melanoma drug works not by attacking the cancer directly, but by removing the cells that stop the immune system from attacking it? This study points to that unexpected possibility.

OverviewIn depth

Performance of a safe and dignified burial intervention during an Ebola epidemic in the eastern Democratic Republic of the Congo, 2018–2019 4:39

Performance of a safe and dignified burial intervention during an Ebola epidemic in the eastern Democratic Republic of the Congo, 2018–2019

Abdihamid Warsame, Gwendolen Eamer, Alaria Kai, Lucia Robles Dios, Hana Rohan, Patrick Keating, Jacques Katshishi, Francesco Checchi

During an Ebola outbreak, a funeral can protect a community, or spread infection. This study found that getting a burial team there quickly was possible, but safety also depended on whether families and neighbours trusted the response.

OverviewIn depth

DeepsmirUD: Prediction of Regulatory Effects on microRNA Expression Mediated by Small Molecules Using Deep Learning 5:10

DeepsmirUD: Prediction of Regulatory Effects on microRNA Expression Mediated by Small Molecules Using Deep Learning

Jianfeng Sun, Jinlong Ru, Lorenzo Ramos‐Mucci, Fei Qi, Zihao Chen, Suyuan Chen, Adam P. Cribbs, Li Deng, Xia Wang

A drug may affect a tiny genetic message by turning its activity up or down, but finding out which direction it takes can require slow, expensive experiments. This study asks whether a computer can make that prediction first.

OverviewIn depth