Highly accurate protein structure prediction with AlphaFold
Every cell depends on proteins, but scientists have seen the shape of only a tiny fraction of them. AlphaFold showed that a sequence of chemical letters can be enough to predict a protein’s three-dimensional form with near-experimental accuracy. For more than fifty years, predicting a protein’s three-dimensional shape from its sequence remained an open problem. AlphaFold changed the scale of what was possible, reaching near experimental accuracy in many cases, even without a similar known structure.