Evaluating the effects of metronidazole, metformin, and onion extract on GAPDH activity and nitric oxide production in Blastocystis sp. cultures: a biochemical and therapeutic approach
Gehad A. Basuony, Alshaimaa Hamed, Amal M. Mahfoz, Abdel Wahab M. Mahmoud, Hala Ramadan, Magda Said Ahmed Abdeltawab
A common gut parasite may be vulnerable not only to its usual medicine, but also to a diabetes drug and onion extract. The surprise is that killing it may involve changing its energy system and its chemical surroundings. What happens when a common antiparasitic drug, a diabetes medicine, and onion extract meet Blastocystis? This study finds that all three can suppress the parasite, but they do not shift its biochemical environment in the same way.