When a tooth is badly infected, the goal is not only to clean it—it is to help the damaged area heal. This study tested whether adding vitamin C would make that healing better, and the answer was unexpectedly even-handed. An infection inside a tooth can spread to the area around its root, often after decay or an injury.

That condition is commonly treated by removing the inner tissue and sealing the tooth. But removing that tissue may leave the treated tooth less structurally durable, making it more prone to fracture and reinfection. The passage points to the inner tissue as important for keeping a tooth healthy over time.

That concern leads to a different idea: treatment can try to support healing inside the tooth. The study tested injectable platelet-rich fibrin combined with vitamin C as a scaffold in regenerative treatment. The study also looked at healing in two kinds of dental images, along with pain after treatment and the tooth’s clinical condition.

The comparison was designed so people were assigned by chance to one of two treatment groups, and both the patients and the people assessing them were kept unaware of the assignment. Everyone gave written consent before taking part, and treatment and follow-up took place in an outpatient clinic from April twenty twenty-three through January twenty twenty-five.

The main question was whether the damaged area around the root looked smaller after treatment, comparing images taken before treatment with images taken twelve months later. The study also assessed healing with another image-based score, ordinary two-dimensional dental images, the tooth’s clinical condition, and pain after treatment.

A dark area near the tooth’s root becomes progressively smaller on repeat X-rays, shrinking from two point eight eight square millimetres before treatment to zero point nine seven at six months. That visible change is consistent with the bone healing around the root.

Here is the first important result: the damaged area became significantly smaller over time in both treatment groups. The size of the improvement was large in both groups, indicating substantial improvement over time regardless of which treatment was used.

The clinical picture was also reassuring. During follow-up, none of the cases in either group showed pain when the tooth was tapped, swelling, or a draining passage. Clinical success was achieved in all cases in both groups. But the result needs a boundary around it.

The relatively modest number of participants may have made it harder to detect small differences between the treatments. And although the follow-up was long enough to assess early healing trends, it may not show whether healing remains stable over much longer periods.

The overall finding is that both the blood-based material alone and the same material supplemented with vitamin C were associated with favorable clinical and image-based outcomes in these damaged mature teeth. No statistically significant difference appeared between the groups for healing around the root, clinical outcomes, or pain after treatment.

Both approaches had favorable clinical outcomes, and no adverse events were observed during follow-up. For someone facing this kind of tooth problem, that means both options showed encouraging short-term results, but vitamin C did not clearly add an advantage.

Both treatments were linked with healing and no troubling symptoms during follow-up, but adding vitamin C did not produce a detectable advantage. For patients, the encouraging part is that both approaches showed favorable short-term results, while longer-term benefit remains uncertain.