Medicine

50 open-access papers in Medicine, free to watch.

Prescriptions of homeopathic remedies at the expense of the German statutory health insurance from 1985 to 2021: scientific, legal and pharmacoeconomic analysis

Prescriptions of homeopathic remedies at the expense of the German statutory health insurance from 1985 to 2021: scientific, legal and pharmacoeconomic analysis

Hauke Leemhuis, Roland Seifert

When public health insurance pays for a treatment, the question is not only whether people want it. It is whether the evidence, the price, and the safety information justify using everyone’s shared money.

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Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations allowing the identification of RAF inhibitors as anti-proliferative drugs

Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations allowing the identification of RAF inhibitors as anti-proliferative drugs

Eva Hoferkova, Václav Šeda, Sona Kadakova, Jan Verner, Tomáš Loja, Kvetoslava Matulova, Hana Skuhrová Francová, Eva Ondroušková, Daniel Filip, Nicolas Blavet, Miroslav Boudný, Gabriela Mladonická Pavlasová, Josef Večeřa, Laura Ondrišová, Petra Pavelkova, Krystof Hlavac, Lenka Košťálová, Androniki Michaelou, Šárka Pospíšilová, Jana Dorazilová, Václav Chochola, Josef Jaroš, Michael Doubek, Marie Jarošová, Aleš Hampl, Lucy Vojtová, Leoš Křen, Jiří Mayer, Marek Mráz

Chronic leukemia cells often stop growing when removed from the body, making them hard to study. This study rebuilt the neighborhood around them, and made their hidden growth behavior visible, then found a drug class that stopped it.

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Association Between Osteoporosis and Adiposity Index Reveals Nonlinearity Among Postmenopausal Women and Linearity Among Men Aged over 50 Years

Association Between Osteoporosis and Adiposity Index Reveals Nonlinearity Among Postmenopausal Women and Linearity Among Men Aged over 50 Years

Po‐Ju Chen, Yueh‐Chien Lu, Sheng‐Nan Lu, Fu‐Wen Liang, Hung‐Yi Chuang

Could carrying more body fat sometimes protect bones, but only up to a point, and differently for women and men? This study finds that the answer is not a simple “more” or “less.”

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Clinical trajectory of intraductal papillary mucinous neoplasms progressing to pancreatic carcinomas during long-term surveillance: a prospective series of 100 carcinoma cases

Clinical trajectory of intraductal papillary mucinous neoplasms progressing to pancreatic carcinomas during long-term surveillance: a prospective series of 100 carcinoma cases

Hiroki Oyama, Tsuyoshi Hamada, Yousuke Nakai, Mariko Tanaka, Go Endo, Ryunosuke Hakuta, Kota Ishida, Kazunaga Ishigaki, Sachiko Kanai, Kohei Kurihara, Tomotaka Saito, Tatsuya Sato, Tatsunori Suzuki, Yukari Suzuki, Shinya Takaoka, Shuichi Tange, Yurie Tokito, Naminatsu Takahara, Tetsuo Ushiku, Mitsuhiro Fujishiro

Regular scans can watch a pancreatic cyst for years, yet a dangerous cancer may still appear without the warning signs doctors expect. This study reveals why surveillance is harder than it looks.

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Identification of the molecular subgroups in Alzheimer's disease by transcriptomic data

Identification of the molecular subgroups in Alzheimer's disease by transcriptomic data

He Li, Meiqi Wei, Tianyuan Ye, Yiduan Liu, Dongmei Qi, Xiaorui Cheng

What if Alzheimer’s disease is not one illness following one path, but several different biological problems hiding under the same diagnosis? This study found three distinct patterns in affected brains.

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Animal models of cancer metastasis to the bone

Animal models of cancer metastasis to the bone

Yihan Yu, Kanglu Li, Yizhong Peng, Wei Wu, Fengxia Chen, Zengwu Shao, Z. Zhang

When cancer reaches bone, the consequences can be devastating: pain, fractures, loss of movement, and sometimes death. To understand how that journey happens, and how to stop it, researchers build living models of it.

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Validation of a novel numerical model to predict regionalized blood flow in the coronary arteries

Validation of a novel numerical model to predict regionalized blood flow in the coronary arteries

Daniel J. Taylor, Jeroen Feher, Krzysztof Czechowicz, Ian Halliday, D. Rodney Hose, Rebecca Gosling, Louise Aubinière-Robb, Marcel van’t Veer, Danielle Keulards, Pim A.L. Tonino, Michel Rochette, Julian Gunn, Paul Morris

A heart artery is not just one pipe carrying one stream of blood. Its smaller branches constantly draw blood away, and a computer model may now estimate where that flow goes, without measuring every drop directly.

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The burden of colorectal cancer attributable to dietary risk in Middle East and North African from 1990 to 2019

The burden of colorectal cancer attributable to dietary risk in Middle East and North African from 1990 to 2019

Yahya Pasdar, Fatemeh Khosravi Shadmani, Hawal Lateef Fateh, Davood Soleimani, Behrooz Hamzeh, Mojtaba Ghalandari, Behrooz Moloudpour, Mitra Darbandi

Bowel cancer is rising in lower- and middle-income countries, and this study finds that the share linked with diet increased across all 21 countries examined. What we eat may be part of a changing regional health story.

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Therapeutic Options for Crigler–Najjar Syndrome: A Scoping Review

Therapeutic Options for Crigler–Najjar Syndrome: A Scoping Review

Vanessa Sambati, Serena Laudisio, Matteo Motta, Susanna Esposito

For some children, staying alive can mean lying under special blue lights for ten to twelve hours every day. This review asks whether future treatments could repair the problem instead of managing it for life.

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Aquaporins in Biliary Function: Pathophysiological Implications and Therapeutic Targeting

Aquaporins in Biliary Function: Pathophysiological Implications and Therapeutic Targeting

Mohamad Khalil, Patrizia Gena, Agostino Di Ciaula, Piero Portincasa, Giuseppe Calamita

Bile is almost entirely water, yet tiny water channels may help decide whether it flows normally, concentrates safely, or contributes to disease. This review asks whether those channels could become treatment targets.

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Hepatitis B Core Antibody Level: A Surrogate Marker for Host Antiviral Immunity in Chronic Hepatitis B Virus Infections

Hepatitis B Core Antibody Level: A Surrogate Marker for Host Antiviral Immunity in Chronic Hepatitis B Virus Infections

Yang Shi, Zihan Wang, Shengxiang Ge, Ningshao Xia, Quan Yuan

A routine blood antibody may reveal more than whether hepatitis B was ever present. Its level may act like a dashboard for how strongly the body is fighting the virus, and how likely treatment is to help.

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Ten-Year Trends in Psychotropic Prescribing and Polypharmacy in Australian General Practice Patients with and without Dementia

Ten-Year Trends in Psychotropic Prescribing and Polypharmacy in Australian General Practice Patients with and without Dementia

Woldesellassie M. Bezabhe, Jan Radford, Mohammed S. Salahudeen, Ivan Bindoff, Tristan Ling, Peter Gee, Barbara C. Wimmer, Gregory M. Peterson

For people with dementia, medicines aimed at distressing behaviour became less common over a decade, but taking several of these medicines at once still affected almost one person in five by the end.

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